The Answer:

The highest current denomination is the $100 bill.

The highest bill ever printed, however, was a $100,000 note that was printed from December 18, 1934 to January 9, 1935. It was used for transactions between Federal Reserve Banks. President Woodrow Wilson was pictured on the front.

The following bills have not been in print since 1946: $500 (William McKinley); $1,000 (Grover Cleveland); $5,000 (James Madison); and $10,000 (Salmon P. Chase, former Treasury Secretary).

Here is a link to more information about the denominations of U.S. paper money.

—The Fact Monster