In 2003 Noory became the host of Coast to Coast AM, a nightly national radio call-in show focused on UFOs, ghosts, and other paranormal topics. Noory took over the show from its original host, late-night legend Art Bell. (Earlier, Noory had filled in as host on some of Bell's off-nights.) Noory previously hosted his own late-night radio show in St. Louis, following an early career in TV news production.

Extra credit: Noory's nickname in St. Louis was 'the Nighthawk.'