Isabeli Fontana began appearing in the Victoria's Secret catalog in 1999 -- reportedly after her youthful good looks caused the company to breach its usual policy of hiring only models aged 21 or older. Isabeli Fontana has modeled commercially for Ralph Lauren and Valentino, among many others, and appeared on the covers of Vogue, Marie Claire and Elle. She was part of the 'Brazilian model invasion' of the late 1990s, in a group including Gisele Bundchen, Ana Claudia Michels and Adriana Lima.

Isabeli Fontana sometimes goes by the one-name moniker 'Isabeli.'