Edward Jenner administered the first smallpox vaccine to 8-year-old James Phipps.
The Lewis and Clark expedition set out from St. Louis.
The Olympic Games were held in the United States for the first time, in St. Louis, Missouri.
British rule in Palestine came to an end as The Jewish National Council proclaimed the State of Israel. Within hours, Israel was under attack from Arab forces.
The Warsaw Pact was signed by the Soviet Union and seven other Communist bloc countries. It finally dissolved in 1991.
Skylab, the United States’ first space station, was launched into orbit.
Frank Sinatra died at the age of 82.