AcmeAc′me
The crisis of a disease. Old medical writers used to divide the
progress of a disease into four periods: the ar-che, or
beginning; the anabasis, or increase, the acme, or term
of its utmost violence, and the pa-rac-me, or decline.
Figuratively, the highest point of anything.
Source: Dictionary of Phrase and Fable, E. Cobham Brewer, 1894 More on Acme from Fact Monster:
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