Anti-Federalists, in American history, opponents of the adoption of the federal Constitution. Leading Anti-Federalists included George Mason, Elbridge Gerry, Patrick Henry, and George Clinton. Later, many of the Anti-Federalists opposed the policies of the Federalist party and of Alexander Hamilton.
See M. Borden, ed., The Antifederalist Papers (1965); C. M. Kenyon, ed., The Antifederalists (1966).
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