In 1585, Drake commanded a fleet that sacked Vigo in Spain and burned São Tiago in the Cape Verde Islands. Proceeding across the Atlantic, he took Santo Domingo and Cartagena (which were subsequently ransomed), plundered the Florida coast, including the settlement of St. Augustine, and rescued Sir Walter Raleigh's Roanoke colony under Ralph Lane on the Carolina coast.
Meanwhile, Spain had begun to prepare for open war. In 1587, Drake entered the harbor of Cádiz with 26 ships and destroyed about 30 of the ships the Spanish were assembling. He had, he said, merely singed the king of Spain's beard and wished to carry out further expeditions against the Spanish ports, but Elizabeth would not sanction his plans. He was a vice admiral in the fleet that defeated the Armada in 1588. He was in joint command of an attempted invasion of Portugal in 1589 but failed to take Lisbon.
Drake's last expedition, in 1595, undertaken jointly with Hawkins, was directed against the West Indies. This time the Spanish were prepared, and the venture was a complete failure. Hawkins died off Puerto Rico, and Drake shortly afterward, of dysentery, off Portobelo, where he was buried at sea.
The Columbia Electronic Encyclopedia, 6th ed. Copyright © 2012, Columbia University Press. All rights reserved.