Henri's brother Louis de Lorraine, Cardinal de Guise, 1555–88, was killed at the same time as Henri. After their deaths the leadership of the League devolved upon their brother, Charles, duc de Mayenne. Henri was succeeded by his son Charles de Lorraine, 4th duc de Guise, 1571–1640.
Henri de Lorraine, 5th duc de Guise, 1614–64, son of the 4th duke, was archbishop of Reims but became duke after the death of his older brother (1639) and of his father. He conspired (1641) against Cardinal Richelieu and was forced to live in exile for a time in Flanders. In 1647 he took part, as representative of the house of Anjou, in the insurrection at Naples against Spanish rule. Captured by the Spanish (1648), he was a prisoner until 1652. He made a new attack on Naples in 1654, then returned to Paris, where, as grand chamberlain, he played a prominent role in the social life of the court. He was succeeded by his nephew, Louis Joseph de Lorraine, 6th duc de Guise, 1650–71. With François Joseph de Lorraine, 7th duc de Guise, 1670–75, son of the 6th duke, the line came to an end.
The Columbia Electronic Encyclopedia, 6th ed. Copyright © 2012, Columbia University Press. All rights reserved.