Henle, Jacob (Friedrich Gustav Jakob Henle)frēˈdrĭkh gŏsˈtäf yäˈkôp hĕnˈlə, 1809–85, German anatomist and histologist. A pupil of J. P. Müller, he taught at Zürich, Heidelberg, and Göttingen. He contributed pioneer work on the microscopic structure of tissues, including the renal tubules that bear his name, epithelium, hair, and blood vessels. He anticipated Pasteur in his theory that microorganisms cause infectious diseases. He wrote Handbuch der systematischen Anatomie (3 vol., 1866–71) and other important works.