vitamin: Vitamin B12

The molecular structure of vitamin B₁₂vitamin B₁₂ (cobalamin), the most complex of all known vitamins, was announced in 1955 by several scientists, including British biochemists A. R. Todd and Dorothy Hodgkin. In 1973 the vitamin was reported to have been synthesized by organic chemists. Vitamin B₁₂ and closely related cobalamins are necessary for folic acid to fulfill its role; both are involved in the synthesis of proteins. American physicians G. R. Minot and W. P. Murphy in 1926 fed large amounts of liver to patients with pernicious anemia and cured them; the curative substance in this case was probably vitamin B₁₂. However, pernicious anemia in humans is caused not by a vitamin B₁₂ deficiency in the diet but rather the absence of a substance called the intrinsic factor, ordinarily secreted by the stomach and responsible for facilitating the absorption of B₁₂ from the intestine. When a person's body cannot produce the intrinsic factor, the standard treatment today is to inject vitamin B₁₂ directly into the bloodstream. Minot and Murphy's therapy worked because the liver they fed their patients contained such large quantities of B₁₂ that sufficient amounts of the vitamin were absorbed without the assistance of the intrinsic factor. Inadequate absorption of B₁₂ causes pernicious anemia, nervous system degeneration, and amenorrhea. The only site of cobalamin synthesis in nature appears to be in microorganisms; neither animals nor higher plants are capable of making these vitamin B₁₂ derivatives. Nevertheless, such animal tissues as the liver, kidney, and heart of ruminants contain relatively large quantities of vitamin B₁₂; the vitamin stored in these organs was originally produced by the bacteria in the ruminant gut. Bivalves (clams or oysters), which siphon microorganisms from the sea, are also good sources. Plants, on the other hand, are poor sources of vitamin B₁₂. The recommended daily dietary allowance for adults is 3 micrograms.

Sections in this article:

• Introduction
• Vitamin K
• Vitamin E
• Vitamin D
• Vitamin C
• Vitamin B12
• Folic Acid
• Biotin
• Pantothenic Acid
• Vitamin B6 Group
• Niacin
• Riboflavin
• Thiamine
• Vitamin B Complex
• Vitamin A
• Bibliography

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