Examples of the transmission of hemophilia have been found in several royal families. The family of Queen Victoria of England and, later, that of her granddaughter the Czarina Alexandra Feodorovna were affected. The apparent ability of Rasputin to check the hemophilia of the czarina's son was the basis of his hold over her and the czar. The family of Alfonso XIII of Spain, who married another granddaughter of Victoria, was also affected.
See S. Pemberton, The Bleeding Disease: Hemophilia and the Unintended Consequences of Medical Progress (2011).
The Columbia Electronic Encyclopedia, 6th ed. Copyright © 2012, Columbia University Press. All rights reserved.