Appleton, city (1990 pop. 65,695), seat of Outagamie co., E Wis., on the Fox River near its exit from the northern end of Lake Winnebago, in a dairying and stockraising region; inc. 1857. Waterfalls provide power for the city's industries, which produce paper, wood, metal, concrete, and dairy products. Appleton had the nation's first hydroelectric plant (1882) and the state's first electric streetcar (1886). The city is the seat of Lawrence Univ.