Steubenville (stōˈbənvĭl) [key], city (1990 pop. 22,125), seat of Jefferson co., E central Ohio, on the Ohio River; laid out c.1797, inc. as a city 1851. Its once significant steel and coking industries have declined; manufactures include tin, metals, chemicals, and paper goods. Bituminous coal is also mined. Of interest is the birthplace of Edwin M. Stanton. The Franciscan Univ. of Steubenville is there.