Winona (wĭnōˈnə, wĪ–) [key], city (1990 pop. 25,399), seat of Winona co., SE Minn., on the Mississippi River; inc. 1857. There is food processing, and construction equipment, fabricated metal products, building materials, textiles, spices and extracts, apparel, and light fixtures are made there. An early trading and lumber center, Winona grew as river traffic increased, and the city developed as a manufacturing and commercial center. St. Mary's Univ. of Minnesota and Winona State Univ. are there. The sculptor James Earle Fraser was born in Winona.