Grahamstown, city, now part and seat of Makana local municipality, Eastern Cape prov., SE South Africa. It manufactures pottery and is the commercial center for a rich agricultural region. Founded in 1819 as a military post on Xhosa land, the Grahamstown area was the site of repeated conflict in the early 19th cent. Rhodes Univ. (1904), an Anglican cathedral, and the Albany Museum, with collections of prehistoric and natural history materials, are in the city.