Guadalupe (gwäˌdəlōpˈ, Span. gwäħälōˈpā) [key], town (1990 pop. 2,652), Cáceres prov., W central Spain, in Extremadura. It is noted for its monastery (formerly Hieronymite, now Franciscan) and the shrine of Our Lady of Guadalupe, whose cult was transferred in the 16th cent. to Guadalupe Hidalgo, Mexico. The area is still a pilgrimage center.