Karshi (kərshēˈ) [key], city (1991 pop. 168,000), S Uzbekistan, on the Kashka-Darya River. It is the center of a fertile oasis that produces wheat, cotton, and silk. Karshi was founded in the 9th cent. as a stop on the caravan route between Samarkand and Afghanistan. It has a 16th-century mosque and mausoleum.