Nikopol (nyĭkôˈpəl) [key], city (1989 pop. 158,000), SE Ukraine, on the Dnieper River. It is a rail terminus and the industrial center of one of the world's richest manganese-mining areas. The city has metallurgical plants, machine tool factories, and food-processing and brewing industries. Nikopol stands on the site of one of the earliest trade routes and strategic crossing points over the Dnieper. Manganese production at Nikopol became important in the 19th cent.