Santa Fe, city (1991 pop. 341,000), capital of Santa Fe prov., NE Argentina, a river port near the Paraná, with which it is connected by canal. On the eastern margin of the Pampa (see under pampas), it is an important shipping point for the agricultural products of much of NW Argentina. The city also has some industry. Founded by the Spanish conquistador Juan de Garay (1573), Santa Fe was the site of the promulgation of the 1853 Argentine constitution. There are several notable churches and a national university.