| Secretary of State | Alexander M. Haig, Jr., 1981 George P. Shultz, 1982 |
| Secretary of the Treasury | Donald T. Regan, 1981 James A. Baker 3rd, 1985 Nicholas F. Brady, 1988 |
| Secretary of Defense | Caspar W. Weinberger, 1981 Frank C. Carlucci, 1987 |
| Attorney General | William French Smith, 1981 Edwin Meese 3rd, 1985 Richard L. Thornburgh, 1988 |
| Secretary of the Interior | James G. Watt, 1981 William P. Clark, 1983 Donald P. Hodel, 1985 |
| Secretary of Agriculture | John R. Block, 1981 Richard E. Lyng, 1986 |
| Secretary of Commerce | Malcolm Baldrige, 1981 C. William Verity, Jr., 1987 |
| Secretary of Labor | Raymond J. Donovan, 1981 William E. Brock, 1985 Ann Dore McLaughlin, 1987 |
| Secretary of Health and Human Services | Richard S. Schweiker, 1981 Margaret M. Heckler, 1983 Otis R. Bowen, 1985 |
| Secretary of Housing and Urban Development | Samuel R. Pierce, Jr., 1981 |
| Secretary of Transportation | Andrew L. Lewis, Jr., 1981 Elizabeth H. Dole, 1983 James H. Burnley 4th, 1987 |
| Secretary of Energy | James B. Edwards, 1981 Donald P. Hodel, 1983 John S. Herrington, 1985 |
| Secretary of Education | T. H. Bell, 1981 William J. Bennett, 1985 Lauro F. Cavazos, 1988 |