/ Dictionary / Index S second derivative: Meaning and Definition of Find definitions for: sec'ond deriv'ative Pronunciation: [key] — Math. Math. the derivative of the derivative of a function:Cf. Acceleration is the second derivative of distance with respect to time. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. second-degree murder second division Related Content Daily Word Quiz: labyrinth Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language