/ Dictionary / Index S self-annihilation: Meaning and Definition of Find definitions for: self-an•ni•hi•la•tion Pronunciation: (self'u-nī"u-lā'shun, self"-), [key] — n. self-destruction; suicide. surrender, abnegation, or immolation of the self in mystic contemplation of or union with God. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: self-annihilation (Thesaurus) self-analyzed self-antigen Related Content Daily Word Quiz: denizen Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language