/ Dictionary / Index S self-destruction: Meaning and Definition of Find definitions for: self-de•struc•tion Pronunciation: (self'di-struk'shun, self"-), [key] — n. the destruction or ruination of oneself or one's life. suicide. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: self-destruction (Thesaurus) self-destruct self-destructive Related Content Daily Word Quiz: nefarious Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language