/ Dictionary / Index S self-destructive: Meaning and Definition of Find definitions for: self-de•struc•tive Pronunciation: (self'di-struk'tiv, self"-), [key] — adj. harmful, injurious, or destructive to oneself: His constant arguing with the boss shows he's a self-destructive person. reflecting or exhibiting suicidal desires or drives: Careless driving may be a self-destructive tendency. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: self-destructive (Thesaurus) self-destruction self-determination Related Content Daily Word Quiz: languid Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language