Although Hippocrates followed the current belief that disease resulted from an imbalance of the four bodily humors , he maintained that the disturbance was influenced by outside forces and that the humors were glandular secretions. He believed that the goal of medicine should be to build the patient's strength through appropriate diet and hygienic measures, resorting to more drastic treatment only when the symptoms showed this to be necessary. This was in contrast to the contemporary Cnidian school, which stressed detailed diagnosis and classification of diseases to the point of ignoring the patient. Hippocrates probably had an inkling of Mendelian and genomic factors in heredity, because he noted not only many of the signs of disease but also that symptoms could appear throughout a family or a community, or even over successive generations.
Of the large collection of writings that derived from the Coan school, only a few are generally ascribed to Hippocrates himself, although his influence is felt throughout. Of these, The Aphorisms, summing up his observations and deductions, and Airs, Waters, and Places, which recognized a link between environment and disease, are considered the most important. The collection has appeared in a number of translations, notably that of Littré.
See studies by W. Smith (1979) and W. Heidel (1981).
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