immortalcell). The resulting hybrid cell, or hybridoma, multiplies rapidly, creating a clone that produces large quantities of the antibody.
Monoclonal antibodies engendered much excitement in the medical world and in the financial world in the 1980s, especially as potential cures for cancer. They have been used in laboratory research and in medical tests since the mid-1970s, but their effectiveness in disease treatment was limited especially by the tendency of the early monoclonal antibodies to provoke an immune response against them because of the use of mouse cells in creating the hybridoma. This problem has been overcome through the use of recombinant DNA to produce chimeric and humanized monoclonal antibodies and of transgenic mice and other techniques to produce human antibodies. Monoclonal antibody therapies have been developed to treat transplant rejection, some autoimmune diseases, and some types of lymphoma, leukemia, and breast and other cancers. These therapies use monoclonal antibodies to home in on specific antigens found on the surface of targeted cells to deliver radioactive materials, drugs or inactive drug precursors (subsequent converted to a drug by an enzyme), tumor-suppressing genes, or substances that suppress or inhibit signaling molecules involved in disease processes.
See study by L. V. Marks (2015).
The Columbia Electronic Encyclopedia, 6th ed. Copyright © 2012, Columbia University Press. All rights reserved.
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