Brice appeared in burlesque and vaudeville from 1906. She starred in the Ziegfeld "Follies" from 1910 onward, and in Broadway shows, emphasizing her plainness by means of a comic awkwardness. In 1937 she created for radio the popular role of Baby Snooks. She appeared in the films My Man (1928), The Great Ziegfeld (1936), and Ziegfeld Follies (1944). Three films have been based on her life, including Funny Girl (1968).
See biography by Norman Katkov (1953).