There are several hundred possible causes of mental retardation. They include genetic conditions (e.g., Down syndrome, fragile X syndrome); prenatal problems (e.g., fetal alcohol syndrome, rubella, malnutrition); problems apparent at birth (e.g., low birth weight and prematurity); and problems that occur after birth (e.g., injuries and childhood diseases like measles that can lead to meningitis and encephalitis). The most commonly identified causes of mental retardation are Down syndrome, fragile X syndrome, and fetal alcohol syndrome. In many cases the cause is never known.
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