10 million people worldwide estimated to be HIV-positive, including 1 million in U.S.; more than 36,000 Americans have died of AIDS since the late 1970s
1992
The first clinical trials using combinations of multiple drugs begin
FDA begins accelerated approval of experimental AIDS drugs
1993
U.S. annual AIDS deaths approach 45,000
1994
AIDS-related illnesses are the leading cause of death for adults 25-44 years old in U.S.
1995
Saquinavir, the first protease inhibitor (which reduces the ability of AIDS to spread to new cells) is approved