Granddaughter of the late television star Cliff Arquette, it is little surprise that both Patricia and her sister Rosanna Arquette both became actresses. After small roles in many films, she moved up to leads in Little Nicky (2000), Lost Highway (1997), Infinity (1996), Flirting With Disaster (1996), True Romance (1993), Tim Burton's Ed Wood (1994), and Beyond Rangoon (1995), which also featured her son Enzo Rossi. She was married to actor Nicolas Cage from 1995 to 2001. She turned to the small screen in 2005 with the NBC series Medium, in which she plays a crime-solving psychic. Her sister is Rosanna Arquette, and her brothers are actors David and Alexis.