Former rock singer Madigan has garnered several stage and film credits, first coming to notice in Love Child (1982). In her next movie (Places in the Heart, 1984) she costarred with her husband, Ed Harris. She was nominated for an Oscar for her performance in Twice in a Lifetime (1985) and then appeared in Field of Dreams (1989). Other films include Pollock (2000), A Time for Dancing (2000) and The Sleepy Time Gal (2001). She is a cast member of the HBO series Carnivàle (2003–2005).