1. calamity, catastrophe, disaster, tragedy, cataclysm, misfortune, bad luck

usage: an event resulting in great loss and misfortune; "the whole city was affected by the irremediable calamity"; "the earthquake was a disaster"

2. tragedy, drama

usage: drama in which the protagonist is overcome by some superior force or circumstance; excites terror or pity

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See also: tragedy (Dictionary)