/ Dictionary / Index C Clayton: Meaning and Definition of Find definitions for: Clay•ton Pronunciation: (klāt'n), [key] — n. 1796–1856, U.S. jurist and politician: senator 1829–36, 1845–49, 1853–56; Secretary of State 1849–50. a city in E Missouri, near St. Louis. 14,219. a male given name. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. clay stone Clayton Antitrust Act Related Content Daily Word Quiz: lyre Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language