/ Dictionary / Index C controlled substance: Meaning and Definition of Find definitions for: controlled' sub'stance Pronunciation: [key] any of a category of behavior-altering or addictive drugs, as heroin or cocaine, whose possession and use are restricted by law. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. controlled-release controller Related Content Daily Word Quiz: foliage Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language