/ Dictionary / Index E endogenous depression: Meaning and Definition of Find definitions for: endog'enous depres'sion Pronunciation: [key] — Psychiatry. Psychiatry. a severe form of depression usually characterized by insomnia, weight loss, and inability to experience pleasure, thought to be of internal origin and not influenced by external events. Also called Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. endogenous endogeny Related Content Daily Word Quiz: feral Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language