/ Dictionary / Index L ligate: Meaning and Definition of Find definitions for: li•gate Pronunciation: (lī'gāt), [key] — -gat•ed, -gat•ing. to bind with or as if with a ligature; tie up (a bleeding artery or the like). Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: ligate (Thesaurus) ligase ligation Related Content Daily Word Quiz: feral Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language