/ Dictionary / Index S Santa Fe: Meaning and Definition of Find definitions for: San•ta Fe Pronunciation: (san'tu fā'), [key] a city in and the capital of New Mexico, in the N part: founded c1605. 48,899. a steam locomotive having a two-wheeled front truck, ten driving wheels, and a two-wheeled rear truck. See table under San•ta Fé Pronunciation: (san'tu fā' Sp. sän'tä fe'), [key] a city in E Argentina. 287,240. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Santa Cruz water lily Santa Fe Springs Related Content Daily Word Quiz: illegible Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language