/ Dictionary / Index S Santa Cruz Islands: Meaning and Definition of Find definitions for: San'ta Cruz' Is'lands Pronunciation: [key] a group of islands in the SW Pacific Ocean, part of the Solomon Islands. 380 sq. mi. (984 sq. km). Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. Santa Cruz de Tenerife Santa Cruz water lily Related Content Daily Word Quiz: topography Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language