/ Dictionary / Index S splenectomy: Meaning and Definition of Find definitions for: sple•nec•to•my Pronunciation: (spli-nek'tu-mē), [key] — pl. -mies. excision or removal of the spleen. Also called Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: splenectomy (Thesaurus) splendor splenetic Related Content Daily Word Quiz: lyceum Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language