/ Dictionary / Index V vacuole: Meaning and Definition of Find definitions for: vac•u•ole Pronunciation: (vak'y-ōl"), [key] — n. Biol. a membrane-bound cavity within a cell, often containing a watery liquid or secretion. See diag. under a minute cavity or vesicle in organic tissue. Random House Unabridged Dictionary, Copyright © 1997, by Random House, Inc., on Infoplease. See also: vacuole (Thesaurus) vacuolation vacuous Related Content Daily Word Quiz: cur Analogy of the Day: Today’s Analogy Spelling Bee: Today’s Spelling Bee Frequently Misspelled Words Frequently Mispronounced Words Easily Confused Words Writing & Language