Invasive candidiasis, a more serious infection, occurs most commonly when Candida fungi invade the bloodstream. Hospital and nursing home patients, such as those with a central venous catheter, in an intensive care unit, with weakened immune system, or taking broad-spectrum antibiotics, are most likely to develop invasive candidiasis. Antifungal medications may be prescribed prophylactically to patients who are likely to develop invasive candidiasis. An invasive infection is typically treated by an echinocandin administered intravenously.
C. auris, another species that causes invasive candidiasis, typically infects the bloodstream, wounds, or the ear, and especially affects individuals with weakened immune systems. First identified in Japan in 2009, it is of concern because most forms of the fungus are drug resistant and some are multidrug resistant; additionally, infection can be difficult to identify from its primary symptoms of fever, aches, and fatigue. It has caused outbreaks in health-care facilities, where it can be difficult to eradicate.
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