thrombolytic drug thrŏm˝bəlĭt´ĭk [key] or clot-dissolving drug, substance, such as streptokinase or tissue plasminogen activator (tPA), that causes the breakdown of blood clots (see thrombosis ) that obstruct the flow of blood through the vessels. Its uses include injection during or shortly after a heart attack or stroke (see infarction ) to prevent clots from blocking blood flow to the heart muscle or brain.
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