Calexico kəlĕkˈsĭkō [key], city (2020 pop. 38,633), Imperial co., S Calif., at the Mexican border; inc. 1908. A port of entry from adjacent Mexicali, Baja California, it is also a trade center for the southern part of the fertile Imperial Valley. Tourism is central to Calexico's economy; smuggling has long been a problem.

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