Lozano studied political science at the University of Oregon and holds an honorary degree from Occidental College. Lozano is the president and chief operating officer of La Opinión, the largest Spanish-language daily newspaper in the U.S., which was founded by her family. She has increased circulation and advertising revenue, and as vice president of Lozano Communications, Inc., the paper's parent company, Lozano has expanded into radio and television. She serves on the board of directors of the Walt Disney Co., the California Health Care Foundation, the National Council of La Raza, the Los Angeles County Museum of Art, and Union Bank of California. In addition, she is a trustee of the SunAmerica Asset Management Corporation, the University of Southern California, and in 2000, she was appointed to the Board of Regents of the University of California. A member of the California State Board of Education from 1999 to 2001, she served as president in 2001. Lozano is also a former director of the Fannie Mae Foundation.