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Pott, Percivall

(Encyclopedia)Pott, Percivall, 1714–88, English surgeon at St. Bartholomew's Hospital. He described a fracture of the ankle subsequently known by his name and a deformity of the spine (Pott's disease) caused by t...

antisense

(Encyclopedia)antisense, DNA or RNA manipulated in a laboratory so that its components (nucleotides) form a complementary copy of normal, or “sense,” messenger RNA (mRNA; see nucleic acid). Antisense techniques...

pharmacology

(Encyclopedia)pharmacology, study of the changes produced in living animals by chemical substances, especially the actions of drugs, substances used to treat disease. Systematic investigation of the effects of drug...

baldness

(Encyclopedia)baldness, thinning or loss of hair as a result of illness, functional disorder, or hereditary disposition; also known as alopecia. Male pattern baldness, a genetic trait, is the most common cause of b...

Bedford, John of Lancaster, duke of

(Encyclopedia)Bedford, John of Lancaster, duke of, 1389–1435, English nobleman; third son of Henry IV of England and brother of Henry V. At the death (1422) of his brother and succession of his 9-month-old nephew...

York, Edmund of Langley, duke of

(Encyclopedia)York, Edmund of Langley, duke of, 1341–1402, fifth son of Edward III of England. He was made (1362) earl of Cambridge, served on expeditions to Spain and France, and married (1372) Isabel, daughter ...

congestive heart failure

(Encyclopedia)congestive heart failure, inability of the heart to expel sufficient blood to keep pace with the metabolic demands of the body. In the healthy individual the heart can tolerate large increases of work...

botulism

(Encyclopedia)botulism bŏchˈəlĭzˌəm [key], acute poisoning resulting from ingestion of food containing toxins produced by the bacillus Clostridium botulinum. The bacterium can grow only in an anaerobic atmosp...

Gloucester, Thomas of Woodstock, duke of

(Encyclopedia)Gloucester, Thomas of Woodstock, duke of, 1355–97, English nobleman; youngest son of Edward III. He was betrothed (1374) to Eleanor, heiress of Humphrey de Bohun, earl of Hereford, and became earl o...

toxic shock syndrome

(Encyclopedia)toxic shock syndrome (TSS). acute, sometimes fatal, disease characterized by high fever, nausea, diarrhea, lethargy, blotchy rash, and sudden drop in blood pressure. It is caused by Staphylococcus aur...